The role of Ap2a2 in PPARα-mediated regulation of lipolysis in adipose tissue

MK Montgomery; J Bayliss; S Keenan; S Rhost; SB Ting; MJ Watt

Journal article

The role of Ap2a2 in PPARα-mediated regulation of lipolysis in adipose tissue

MK Montgomery, J Bayliss, S Keenan, S Rhost, SB Ting, MJ Watt

FASEB Journal | WILEY | Published : 2019

DOI: 10.1096/fj.201900909RR

Abstract

Adipose tissue plays a major role in the regulation of systemic metabolic homeostasis, with the AP2 adaptor complex being important in clathrin-mediated endocytosis (CME) of various cell surface receptors, including glucose transporter 4, the insulin receptor, and β-adrenergic receptors (ARs). One of the AP2 subunits, adaptor-related protein complex 2, α2 subunit (Ap2a2), has recently been identified as a peroxisome proliferator-activated receptor (PPAR)α target gene. The effects of PPARα on the AP2 adaptor complex and CME are unknown. We generated adipocyte-specific Ap2a2 knockout mice and investigated their metabolism when fed a standard chow or high-fat diet, without and with supplementat..

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University of Melbourne Researchers

Magda Montgomery Author

Jacqueline Bayliss Author

Stacey Keenan Author

Matt Watt Author

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Grants

Awarded by National Health and Medical Research Council

Funding Acknowledgements

The authors acknowledge support by research fellowships and project grants from the Australian National Health and Medical Research Council (NHMRC) (APP1077703 to M.J.W., APP1006420 and APP1047554 to S.B.T., and APP1143224 to M.K.M.). S.B.T. and M.J.W. share senior authorship. The authors declare no conflicts of interest.